Electrocardiogram (ECG) is used to record the electrical activity of heart. If the instrument monitoring the signal for a long time, it will produce large amount of data. So, the effective lossless ECG compression system can help to reduce the storage space. This brief presents a hardware architecture of multi-channel lossless ECG compression system. The system is based on the algorithm including multi-channel linear prediction and adaptive linear prediction. Also, Golomb rice code (GRC) is used for entropy coding. The hardware implementation has been designed with low hardware complexity usage while using optimum hardware resources. And the architecture can process multiple channels in parallel that can obtain the high throughput. PTB database has been used for verification and testing purposes. This design was implemented in TSMC 180nm. The implementation results show the gate count is 476K and power consumption is 69.18μW while working frequency is 1 KHz.