In modulated wideband converter (MWC), all signals are aliased and sampled indiscriminately, which reduces the reconstruction accuracy of target signal. The focused compressed sampling uses optimized mixing sequence to increase the mixing gain of the target signal. To establish the sequence library with selective characteristics, this brief analyzes the signal components aliased into baseband, then proposes a sequence optimization method based on the greedy algorithm. Simulation and experiments show that the optimized sequence possesses a high gain for a desired frequency band signal. In the three-carrier signal test, as the approximate desired signal power ratio (DSR) is raised to 0.99 in baseband, the normalized mean square error (NMSE) of the reconstructed desired signal is improved by nearly 10 dB compared to using pseudorandom sequences.