In this brief, a four-port MIMO (Multiple Input Multiple Output) Dielectric Resonator Antenna (DRA) integrated cognitive radio (CR) concept is designed and analyzed. It is the first time when CR concept is integrated with a dielectric resonator-based MIMO antenna. The use of a multipurpose reconfigurable filter design within the feeding structure makes it suitable for both interweave and underlay operations of CR. The proposed antenna is designed over an FR4 substrate. After doing the rigorous simulation process, it is confirmed that the DR-based MIMO antenna (when the feeding structure behaves as all-pass filters) operates over a wide frequency range, i.e., 2.5-5.8 GHz. In the case of interweave operation; the proposed antenna shows narrow pass band tunability between 3.2-4.3 GHz. In the case of underlay operation; it shows band rejection tunability between 2.5-4.5 GHz. The proposed antenna can be efficiently used for a Sub-6.0 GHz 5G Communication system.