This work proposes a novel event-triggered exponential supertwisting algorithm (ESTA) for path tracking of a mobile robot. The proposed work is divided into three parts. In the first part, a fractional-order sliding surface-based exponential supertwisting event-triggered controller has been proposed. Fractional-order sliding surface improves the transient response, and the exponential supertwisting reaching law reduces the reaching phase time and eliminates the chattering. The event-triggering condition is derived using the Lipschitz method for minimum actuator utilization, and the interexecution time between two events is derived. In the second part, a fault estimator is designed to estimate the actuator fault using the Lyapunov stability theory. Furthermore, it is shown that in the presence of matched and unmatched uncertainty, event-trigger-based controller performance degrades. Hence, in the third part, an integral sliding-mode controller (ISMC) has been clubbed with the event-trigger ESTA for filtering of the uncertainties. It is also shown that when fault estimator-based ESTA is clubbed with ISMC, then the robustness of the controller increases, and the tracking performance improves. This novel technique is robust toward uncertainty and fault, offers finite-time convergence, reduces chattering, and offers minimum resource utilization. Simulations and experimental studies are carried out to validate the advantages of the proposed controller over the existing methods.