This paper describes the structure and the underlying rationale of a new course dedicated to capability maturity model integration (CMMI)-directed design of wireless sensor networks (WSNs)-based biomedical applications that stresses: 1) engineering-, medico-engineering-, and informatics-related issues; 2) design for general- and special-purpose systems; and 3) the creation of synergistic effects that enable formation of entrepreneurial multidisciplinary teams able to organize and implement the development of these health-related pervasive computing applications. Formal education so far still focuses on treating only strictly separated and specialized topic areas. However, as the need for cooperation and mutual learning between students oriented toward different fields grows, the need for a multidisciplinary educational approach becomes more and more important. For a technical education to be complete, it is no longer enough to train scientists and engineers solely in technical areas. In development and implementation of technology-driven applications, multidisciplinary issues should be properly addressed in the academic sense. The interdisciplinary understanding and synergy achieved are tested through examinations and workshops. The transdisciplinary knowledge improvement is also statistically evaluated, using a system of metrics developed experimentally.