This special issue, organized by Carlo Mastroianni, Franco Cicirelli, Min Jia, Sabita Maharjan, and Ian Taylor, offers a selection of excellent articles in the field of Edge Intelligence and its exploitation for the design and development of sustainable and smart environments. Edge Computing is emerging due to the widespread availability of computational resources, mobile devices, sensors and actuators that are pervasively deployed and today amount to more than 7 billion interfaces in the network. Edge Computing enables the pushing of computation to the edge of the network, away from data centers and close to people and data sources. Edge Intelligence derives from the convergence of Edge Computing with the exploitation of artificial intelligence methodologies and cognitive technologies, involving sensing/actuation, learning and reasoning on distributed data and Internet of Things (IoT) devices.