The ozone mapping and profiler suite (OMPS) is carried onboard the Suomi National Polar-orbiting Partnership satellite that was launched on October 28, 2011. The OMPS mission objectives concern atmospheric ozone concentrations and their variations in the earth atmosphere. A successful thorough on-orbit sensor calibration enabled current validated operational sensor data record (SDR) stage, providing quality sensor data that meet the requirements and users' expectations. The calibration coefficients derived from this paper have been successfully used in a life-cycle SDR reprocessing to improve sensor data quality. In this paper, we present our qualitative analyses and the results of OMPS nadir mapper SDR on-orbit calibration, and address current SDR data quality in relation to instrument detector performance, stray light correction, and wavelength registration. Our OMPS SDR calibration experience sets a reference for the successor instruments for accurate long-term monitoring of ozone total column concentrations.