Subpixel mapping (SPM) is a useful technique that can interpret the spatial distribution inside mixed pixels and produce a finer-resolution classification map for hyperspectral remote-sensing imagery. However, SPM is essentially an ill-posed problem that requires additional information to produce the unique solution. The limited information of a single image is insufficient to make the mapping problem well posed, whereas the complementary spatial information of multiple shifted images is able to reduce the uncertainty and generate an accurate map. The maximum a posteriori model is a feasible way to incorporate auxiliary information for SPM with multiple shifted images, but it introduces a sensitive regularization parameter, which is difficult to preset. Furthermore, the fixed parameter in the iterations influences the incorporation of the multiple images and the spatial prior. In this article, to address these issues, a multiobjective SPM framework for use with multiple shifted hyperspectral images (MOMSM) is proposed. In the proposed algorithm, a multiobjective model consisting of two objective functions, i.e., data fidelity and spatial prior terms, is constructed to transform the SPM into a multiobjective optimization problem, to get rid of the sensitive regularization parameter. To simultaneously optimize the two objective functions, a multiobjective memetic algorithm with a local search operator and an adaptive global replacement strategy is proposed. The multiple images and spatial information can be dynamically fused and the optimal mapping solution with a good balance between the two objectives can be finally obtained. Experiments conducted on both synthetic and real data sets confirm that the proposed method outperforms the other tested SPM algorithms.