Owing to the highly maneuvering character involved in targets, the nonuniform 3-D rotation motions make the assumption that the image projection plane (IPP) is constant during coherent processing interval (CPI) invalid. In this work, an efficient approach is proposed in ISAR imaging for highly maneuvering targets with nonstationary IPP. First, to reasonably describe the mobility of a highly maneuvering motion target, the geometry and signal model with nonstationary IPP are established, where the high-order phase model is deduced to describe the 2-D spatial-variant phase errors. Second, based on the developed signal model, considering the cost function obtained via conventional image entropy with local extremum, the subarray averaging operation in conjunction with entropy is utilized to accelerate the global optimal convergence. Finally, the accurate 2-D spatial-variant phase errors compensation terms are generated to produce the well-focused ISAR images. Compared with existing methods, the main advantages of this work are: 1) the geometry and signal model of the target with nonstationary IPP are established; 2) the subarray averaging operation in conjunction with image entropy is utilized to accelerate the global optimal convergence; and 3) the high-order signal model is derived to present the 2-D spatial-variant phase errors. Several numerical experiments using simulated data and electromagnetic data are conducted to demonstrate the validity of the proposed algorithm and signal model.