A high-efficiency fuel-cell power-generation system with an active-clamp flyback-forward converter is presented in this paper to boost a 12-V dc voltage into a 220-V 50-Hz ac voltage. The proposed system includes a high-efficiency high-step-up interleaved soft-switching flyback-forward converter and a full-bridge inverter. The front-end active-clamp flyback-forward converter has the advantages of zero-voltage-switching performance for all the primary switches, reverse-recovery-problem alleviation for the secondary output diodes, large voltage-conversion ratio, and small input-current ripple. Furthermore, there are two coupled inductors in the proposed converter. Each coupled inductor can work in the flyback mode when the corresponding main switch is in the turn-on state and in the forward mode when it is in the turnoff state, which takes full use of the magnetic core and improves the power density. In addition, the full-bridge inverter with an LC low-pass filter is adopted to provide low-total-harmonic-distortion ac voltage to the load. Therefore, high-efficiency and high-power-density conversion can be achieved in a wide input-voltage range by employing the proposed system. Finally, a 500-W prototype and another 1-kW converter are implemented and tested to verify the effectiveness of the proposed system.