An autodisturbance-rejection control (ADRC) of an induction motor based on an ant colony optimization (ACO) algorithm is proposed in this paper, in order to realize the precise decoupling of the induction motor and the disturbance compensation. A novel control method employs ACO as an automatic tune mechanism for an ADRC controller. According to the feedback information from the induction motor, an optimal solution can be achieved via the optimization mechanism and self-learning ability of ACO after the iterative calculation; therefore, the reliance of the ADRC controller on parameters can be reduced. The simulation and experimental results indicate that the robustness of the proposed optimal design method for ADRC is better than that of the conventional ADRC when the disturbances occur and that the method is feasible and effective.