Through the Industrial Internet of Things (IIoT), a smart factory has entered the booming period. However, as the number of nodes and network size become larger, the traditional IIoT architecture can no longer provide effective support for such enormous system. Therefore, we introduce the Blockchain architecture, which is an emerging scheme for constructing the distributed networks, to reshape the traditional IIoT architecture. First, the major problems of the traditional IIoT architecture are analyzed, and the existing improvements are summarized. Second, we introduce a security and privacy model to help design the Blockchain-based architecture. On this basis, we decompose and reorganize the original IIoT architecture to form a new multicenter partially decentralized architecture. Then, we introduce some relative security technologies to improve and optimize the new architecture. After that we design the data interaction process and the algorithms of the architecture. Finally, we use an automatic production platform to discuss the specific implementation. The experimental results show that the proposed architecture provides better security and privacy protection than the traditional architecture. Thus, the proposed architecture represents a significant improvement of the original architecture, which provides a new direction for the IIoT development.