Efficient imaging techniques aimed at the increasing of the image contrast of a structure, surrounded by a scattering medium, using optically active and high index of refraction molecules as molecular contrast agents, are presented. Specifically, an enhanced degree of linear polarization (DOLP) target detection and imaging is obtained by doping the surrounding medium with molecular contrast agents consisting of aqueous glucose, aqueous alcohol, and salt molecules, in conjunction with advanced polarimetric imaging techniques. The outcome of this paper opens new horizons in the areas of imaging, with emphasis on medical arena, industry, and detection technology.