In the future, vehicles will be equipped with increasingly advanced interactive intelligent electronic devices, which will induce drivers to conduct secondary tasks, thereby leading to distractions. Therefore, the detection and early warning of driver distraction are essential for improving driving safety and pose an important challenge in intelligent transportation systems. Previous studies used traditional machine learning and deep learning transfer models, which have the disadvantages of complicated and time-consuming manual feature engineering, strong subjectivity, and weak generalization performance. In this paper, we propose a fine-grained detection method for driver distraction based on neural architecture search. First, we design an automatic construction algorithm for deep convolutional neural networks based on neural architecture search, which automatically searches for the optimal deep convolutional neural network architecture without human involvement. In addition, we fuse driver-related multisource perception information, use an automatically constructed deep convolutional neural network to extract high-dimensional mapping features, and implement fine-grained detection of various types of driver distraction states. The results on a large-scale multimodal driver distraction dataset demonstrate that our method can efficiently search an optimal deep convolutional neural network, which can quickly converge, and can accurately detect the considered types of driver distraction states, the average detection accuracy reaches 99.7796%; moreover, it has satisfactory robustness.