The fifth generation New Radio vehicle-to-everything (5G NR-V2X) has higher requirements for delay and reliability, which brings challenges to the physical layer signal processing. Mobile edge computing (MEC) can provide larger capacity data storage and more efficient computation through localization of on-board unit (OBU) and next generation Node B (gNB) services. This paper combines the channel estimation of New Radio vehicle-to-infrastructure (NR-V2I) communication baseband signal processing with MEC and designs an intelligent channel estimation framework. In the MEC server, this paper proposes a channel estimation algorithm based on deep learning. This algorithm uses a one-dimensional convolutional neural network (1D CNN) to complete frequency-domain interpolation and conditional recurrent unit (CRU) for time-domain state prediction. Additional velocity coding vector and multipath coding vector track changes in the environment, and accurately train channel data in different mobile environments. System simulation and analysis show that the proposed algorithm improves the channel estimation accuracy, reduces the bit error rate, and enhances the robustness compared with the representative channel estimation algorithms for NR-V2I.