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Selective Deblurring for Improved Calcification Visualization and Quantification in Carotid CT Angiography: Validation Using Micro-CT | IEEE Journals & Magazine | IEEE Xplore

Selective Deblurring for Improved Calcification Visualization and Quantification in Carotid CT Angiography: Validation Using Micro-CT


Abstract:

Visualization and quantification of small structures with computed tomography (CT) is hampered by the limited spatial resolution of the system. Histogram-based selective ...Show More

Abstract:

Visualization and quantification of small structures with computed tomography (CT) is hampered by the limited spatial resolution of the system. Histogram-based selective deblurring (HiSD) is a deconvolution method that restores small high-density structures, i.e., calcifications, of a CT image, using the high-intensity voxel information of the deconvolved image, while preserving the original hounsfield Units (HUs) in the remaining tissues. In this study, high resolution micro-CT data are used to validate the potential of HiSD to improve calcium visualization and quantification in the carotid arteries on in vivo contrast-enhanced CTA data. The evaluation is performed qualitatively and quantitatively on 15 atherosclerotic plaques obtained from ten different patients. HiSD in combination with vessel segmentation significantly improves calcification visualization and quantification on in vivo contrast-enhanced CT images. Calcification blur is reduced, while avoiding noise amplification and edge-ringing artifacts in the surrounding tissues. Calcification quantification errors are reduced by 23.5% on average.
Published in: IEEE Transactions on Medical Imaging ( Volume: 28, Issue: 3, March 2009)
Page(s): 446 - 453
Date of Publication: 07 October 2008

ISSN Information:

PubMed ID: 19244016

References

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