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Magnetic Particle Imaging With Tailored Iron Oxide Nanoparticle Tracers | IEEE Journals & Magazine | IEEE Xplore

Magnetic Particle Imaging With Tailored Iron Oxide Nanoparticle Tracers


Abstract:

Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging te...Show More

Abstract:

Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2*-weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3 × greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.
Published in: IEEE Transactions on Medical Imaging ( Volume: 34, Issue: 5, May 2015)
Page(s): 1077 - 1084
Date of Publication: 25 November 2014

ISSN Information:

PubMed ID: 25438306

Funding Agency:


References

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