The twin support vector machine (TSVM) is widely used in classification problems, but it is not efficient enough for large-scale data sets. Furthermore, to get the optimal parameter, the exhaustive grid search method is applied to TSVM. It is very time-consuming, especially for multiparameter models. Although many techniques have been presented to solve these problems, all of them always affect the performance of TSVM to some extent. In this paper, we propose a safe screening rule (SSR) for linear-TSVM, and give a modified SSR (MSSR) for nonlinear TSVM, which contains multiple parameters. The SSR and MSSR can delete most training samples and reduce the scale of TSVM before solving it. Sequential versions of SSR and MSSR are further introduced to substantially accelerate the whole parameter tuning process. One important advantage of SSR and MSSR is that they are safe, i.e., we can obtain the same solution as the original problem by utilizing them. Experiments on eight real-world data sets and an imbalanced data set with different imbalanced ratios demonstrate the efficiency and safety of SSR and MSSR.