In this paper, identification and control for a class of nonlinear systems with unknown constant or variable control gains are investigated. By reformulating the original system dynamic equation into a new form with a unit control gain and introducing a set of filtered variables, a novel neural network (NN) estimator is constructed and a new estimation error is used to update the augmented weights. Based on the identification results, two singularity-free NN indirect adaptive controllers are developed for nonlinear systems with unknown constant control gains or variable control gains, respectively. Because the singularity problem is eradicated, the proposed methods remove limitations on parameter estimates that are used to guarantee the positiveness of the estimated control gain. Consequently, a more accurate estimation result can be achieved and the system state can track the given reference signal more precisely. The effectiveness of the proposed identification and control algorithms are tested and the superiority of the proposed singularity-free approach is demonstrated by simulation results.