In this article, a low-cost quadruple-node-upsets resilient latch (LCQRL) design is proposed. To meet the high-reliability demands of safety-critical applications, the latch integrates nine soft-error-interceptive modules (SIMs) to form robust feedback loops, ensuring complete resilience to quadruple-node upsets (QNUs). Each Sim comprises ten CMOS transistors and a clocked inverter. Notably, C-element (CE) and dual interlocked storage cell (DICE) modules are not employed in this circuit, resulting in a small area and low power consumption. The simulation results verify the complete QNU self-recoverability and cost-effectiveness of this design. Compared with the existing radiation-hardened QNU resilient latches, the LCQRL latch demonstrates significant improvements in area, power consumption, and area-power–delay product (APDP) by 47.8%, 63%, and 75.5%, respectively. Furthermore, it exhibits low sensitivity to process, voltage, and temperature (PVT) variations.