The performance problems of recent transport protocols applied in fixed and high-speed wireless networks call for research for an effective congestion control approach, which is able to work efficiently in both domains. In this paper we propose a framework incorporating a novel Multi-Domain congestion control with a novel Lightweight Performance Enhancing Proxy (PEP), which requires no client modification. The method was implemented in the Linux kernel and the Lightweight PEP in ns-3 and we carried out a comprehensive performance evaluation of our proposed framework. We demonstrate that our approach can achieve a robust behavior in the presence of wireless loss while keeping the TCP fairness in the wired domain. Moreover, we also present that our method provides a faster adaptation in the wireless domain compared to the currently used CUBIC TCP.