Routing protocol design is very important in network design, because an effective routing protocol can greatly improve network performance. As heavy and aggregated load and interference will decrease the performance, to balance load and interference, an effective load- and interference-balance hybrid routing protocol (LIB-HRP) is proposed in this paper. Unlike existing hybrid routing protocols, LIB-HRP considers the load condition at interfering nodes, because the interfering node with heavy load will have much influence on the current node. The heavier load condition at interfering node can bring a longer duration of interference. Besides, as mesh clients have limited energy, energy condition is taken into account for mesh clients in the proposed approach. Simulation results show that LIB-HRP can obtain better performance in terms of average packet loss ratio, delay, network throughput and energy consumption.