This paper explores the fundamental relationships between Six Sigma and simulation. A basic overview of Six Sigma includes: 1. Six Sigma philosophy, 2. Basic tools, 3. Theory of variation, 4. SPC, 5. Process capability, 6. Six Sigma infrastructure, and 7. DMAIC and DFSS processes. Simulation is applied to the appropriate areas of the overview. Improvement in the robustness of the Six Sigma methodology is discussed and the strengths of simulation are presented as capable and preferable enhancements to the Six Sigma processes. Quotes from Six Sigma and industry leaders are presented. Simulation is presented as an innovation tool enhancing the Six Sigma DMAIC and DFSS processes.