This research proposes and tests an integrated framework for bottom-up simulation of performance in construction projects. The proposed framework conceptualizes construction projects as systems-of-systems in which the abstraction and micro-simulation of dynamic behaviors are investigated at the base-level consisting of the following elements: human agents, information, and resources. The application of the proposed framework is demonstrated in a numerical example related to a tunneling project. The findings highlight the capability of the proposed framework in providing an integrated approach for bottom-up simulation of performance in construction projects.