The growing epidemic of drug shortages in the United States causes challenges for providers all across the critical health care infrastructure and demonstrates the lack of resiliency within drug delivery supply chains. With many drugs having no acceptable substitute, drug shortages directly translate to a public health and safety risk. One of the understudied elements driving this crisis is the role of human behavior and human decision making across the supply chain echelons. We propose an integrated simulation framework which allows for instantiating, testing, and improving supply chains when accounting for human components of the system. We demonstrate the potential insights that can be obtained with our method through several experiments in which supply chain decision makers account for how others might react to their decisions.