Characterizing cartilage microarchitecture on phase-contrast x-ray computed tomography using deep learning with convolutional neural networks

Botao Deng; Anas Z. Abidin; Adora M. D'Souza; Mahesh B. Nagarajan; Paola Coan; Axel Wismüller

doi:10.1117/12.2254645

3 March 2017 Characterizing cartilage microarchitecture on phase-contrast x-ray computed tomography using deep learning with convolutional neural networks

Botao Deng, Anas Z. Abidin, Adora M. D'Souza, Mahesh B. Nagarajan, Paola Coan, Axel Wismüller

Author Affiliations +

Proceedings Volume 10134, Medical Imaging 2017: Computer-Aided Diagnosis; 1013412 (2017) https://doi.org/10.1117/12.2254645
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

The effectiveness of phase contrast X-ray computed tomography (PCI-CT) in visualizing human patellar cartilage matrix has been demonstrated due to its ability to capture soft tissue contrast on a micrometer resolution scale. Recent studies have shown that off-the-shelf Convolutional Neural Network (CNN) features learned from a nonmedical data set can be used for medical image classification. In this paper, we investigate the ability of features extracted from two different CNNs for characterizing chondrocyte patterns in the cartilage matrix. We obtained features from 842 regions of interest annotated on PCI-CT images of human patellar cartilage using CaffeNet and Inception-v3 Network, which were then used in a machine learning task involving support vector machines with radial basis function kernel to classify the ROIs as healthy or osteoarthritic. Classification performance was evaluated using the area (AUC) under the Receiver Operating Characteristic (ROC) curve. The best classification performance was observed with features from Inception-v3 network (AUC = 0.95), which outperforms features extracted from CaffeNet (AUC = 0.91). These results suggest that such characterization of chondrocyte patterns using features from internal layers of CNNs can be used to distinguish between healthy and osteoarthritic tissue with high accuracy.

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Botao Deng, Anas Z. Abidin, Adora M. D'Souza, Mahesh B. Nagarajan, Paola Coan, and Axel Wismüller "Characterizing cartilage microarchitecture on phase-contrast x-ray computed tomography using deep learning with convolutional neural networks", Proc. SPIE 10134, Medical Imaging 2017: Computer-Aided Diagnosis, 1013412 (3 March 2017); https://doi.org/10.1117/12.2254645

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