Is hippocampus getting bumpier with age: a quantitative analysis of fine-scale dentational feature under the hippocampus on 552 healthy subjects

Shuxiu Cai; Xiaxia Yu; Qiaochu Zhang; Chuan Huang; Yi Gao

doi:10.1117/12.2512701

15 March 2019 Is hippocampus getting bumpier with age: a quantitative analysis of fine-scale dentational feature under the hippocampus on 552 healthy subjects

Shuxiu Cai, Xiaxia Yu, Qiaochu Zhang, Chuan Huang, Yi Gao

Author Affiliations +

Proceedings Volume 10949, Medical Imaging 2019: Image Processing; 1094935 (2019) https://doi.org/10.1117/12.2512701
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Shown in high resolution images, a morphological feature that can be clearly observed is the bumpy ridges on the inferior aspect of hippocampus, which we refer to as hippocampal dentation. The dentations of the hippocampus in normal individuals vary greatly from highly smooth to highly dentated. The degree of dentation could be an interesting feature which has been shown to be correlated with episodic memory performance and not to be correlated with hippocampal volume. Here we presented a study which quantitatively evaluated the degree of bumpiness under the hippocampi in 552 healthy subjects with the age of mid-20 to 80. Specifically, the principal component analysis (PCA) which is nonlinearly fitted for quantifying the magnitude and the frequency of the hippocampal dentations has been used to identify the major axes of the hippocampus and the dentations under it. Preliminary results have demonstrated that the level of dentations varies between left and right hippocampi in subjects, as well as across different age groups. This can establish an objective and quantitative measurement for such a feature and can be extended for future comparisons between non-clinical and clinical groups.

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Shuxiu Cai, Xiaxia Yu, Qiaochu Zhang, Chuan Huang, and Yi Gao "Is hippocampus getting bumpier with age: a quantitative analysis of fine-scale dentational feature under the hippocampus on 552 healthy subjects", Proc. SPIE 10949, Medical Imaging 2019: Image Processing, 1094935 (15 March 2019); https://doi.org/10.1117/12.2512701

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