Developing a computer-aided image analysis and visualization tool to predict region-specific brain tissue “at risk” for developing acute ischemic stroke

Gopichandh Danala; Morteza Heidari; Faranak Aghaei; Bappaditya Ray; Bin Zheng

doi:10.1117/12.2512850

15 March 2019 Developing a computer-aided image analysis and visualization tool to predict region-specific brain tissue “at risk” for developing acute ischemic stroke

Gopichandh Danala, Morteza Heidari, Faranak Aghaei, Bappaditya Ray, Bin Zheng

Author Affiliations +

Proceedings Volume 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging; 109530M (2019) https://doi.org/10.1117/12.2512850
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Advent of advanced imaging technology and better neuro-interventional equipment have resulted in timely diagnosis and effective treatment for acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, objective clinicoradiologic correlate to identify appropriate candidates and their respective clinical outcome is largely unknown. The purpose of the study is to develop and test a new computer-aided detection algorithm to quantify region-specific AIS and “at risk” brain volumes prior to thrombectomy using CT perfusion imaging protocol. Fourteen patients with LVO related AIS and assessed radiologically for their eligibility to undergo mechanical thrombectomy was retrospectively analyzed for the study. First, the scheme automatically categorizes images into multiple series of scans acquired from a section of brain. Each image in series is labeled to a specified brain location. Next, image segmentation is performed to separate brain region from skull. The brain is then split into left and right hemispheres, followed by detecting amount of blood in each hemisphere. Last, comparison between amount of blood in each hemisphere over the series of scans is made to observe the wash-in and wash-out rate of blood to assess the extent of already damaged and “at risk” brain tissue. By integrating the scheme into a user graphic interface, the study builds a unique image feature analysis and visualization tool to observe and quantify the delayed or reduced blood flow (brain “at risk” to develop AIS) in the corresponding hemisphere, which has potential to assist radiologists to quickly visualize and more accurately assess the extent of AIS.

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Gopichandh Danala, Morteza Heidari, Faranak Aghaei, Bappaditya Ray, and Bin Zheng "Developing a computer-aided image analysis and visualization tool to predict region-specific brain tissue “at risk” for developing acute ischemic stroke ", Proc. SPIE 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, 109530M (15 March 2019); https://doi.org/10.1117/12.2512850

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