Study of separation between ex vivo malignant and benign prostatic tissue using magnetic resonance electrical property tomography

Ethan K. Murphy; Elias S. Hyams; Alan R. Schned; Jason Pettus; Ryan Halter

doi:10.1117/12.2512897

15 March 2019 Study of separation between ex vivo malignant and benign prostatic tissue using magnetic resonance electrical property tomography

Ethan K. Murphy, Elias S. Hyams, Alan R. Schned, Jason Pettus, Ryan Halter

Author Affiliations +

Proceedings Volume 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging; 109532C (2019) https://doi.org/10.1117/12.2512897
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Magnetic Resonance Electrical Properties Tomography (MREPT) is an imaging modality that uses MR data to directly calculate the conductivity of the imaged object. This study evaluates if MREPT can be used to image differences between cancerous and benign prostate tissue. A total of 39 freshly excised prostates were imaged. MR data and four MREPT approaches were analyzed. Including a new MREPT approach that overlaps tiles (subdomains) resulting in an efficient approach that minimizes artifacts. No direct threshold value was found to differentiate the malignant from benign tissues. However, significance differences were found when comparing malignant and benign differences (differenced on a per slice basis), which reveals there are measurable differences between the two tissues. Ongoing work aims to develop a calibration technique that can exploit these differences so that malignant tissue can be robustly identified.

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Ethan K. Murphy, Elias S. Hyams, Alan R. Schned, Jason Pettus, and Ryan Halter "Study of separation between ex vivo malignant and benign prostatic tissue using magnetic resonance electrical property tomography", Proc. SPIE 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, 109532C (15 March 2019); https://doi.org/10.1117/12.2512897

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KEYWORDS

Tissues

Prostate

Magnetic resonance imaging

Cancer

Pathology

Tumors

Magnetism

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