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4 April 2022 Linked psychopathology-specific factors and individual structural brain abnormalities in schizophrenia
Lin Chai, Yaping Wang, Weiyang Shi, Yu Zhang, Bing Liu, Tianzi Jiang, Lingzhong Fan
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Proceedings Volume 12033, Medical Imaging 2022: Computer-Aided Diagnosis; 1203323 (2022) https://doi.org/10.1117/12.2612266
Event: SPIE Medical Imaging, 2022, San Diego, California, United States
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Abstract
Numerous studies have demonstrated substantial inter-individual symptom heterogeneity among patients with schizophrenia, which seriously affects the quantification of diagnosis and treatment schema. Normative model is a statistical model offering quantitative measurements of abnormal deviations under interindividual heterogeneity. Here, we explored the individual-specific associations among morphologic deviations from normative ranges of brain structure and specific symptomatology structure on three different dimensions without the effect of general disease effects. Specifically, we employed an exploratory bi-factor model for the PANSS scale and built normative models for two cortical measurements: cortical area and thickness. Significant correlations among different cortical measurements and latent symptom groups were observed, which could provide evidence to understand the pathophysiology of schizophrenia symptoms.
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Lin Chai, Yaping Wang, Weiyang Shi, Yu Zhang, Bing Liu, Tianzi Jiang, and Lingzhong Fan "Linked psychopathology-specific factors and individual structural brain abnormalities in schizophrenia", Proc. SPIE 12033, Medical Imaging 2022: Computer-Aided Diagnosis, 1203323 (4 April 2022); https://doi.org/10.1117/12.2612266
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KEYWORDS
Factor analysis
Brain
Statistical analysis
Statistical modeling
Cognitive modeling
Mental disorders
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