Assessing the impact of correlated noise in digital mammography: a virtual clinical trial

Lucas E. Soares; Renann F. Brandao; Lucas R. Borges; Renato F. Caron; Bruno Barufaldi; Andrew D. A. Maidment; Marcelo A. C. Vieira

doi:10.1117/12.2654111

3 April 2023 Assessing the impact of correlated noise in digital mammography: a virtual clinical trial

Lucas E. Soares, Renann F. Brandao, Lucas R. Borges, Renato F. Caron, Bruno Barufaldi, Andrew D. A. Maidment, Marcelo A. C. Vieira

Author Affiliations +

Proceedings Volume 12467, Medical Imaging 2023: Image Perception, Observer Performance, and Technology Assessment; 1246714 (2023) https://doi.org/10.1117/12.2654111
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Conference Poster

Abstract

In digital mammography, the physics of the acquisition system and post-processing algorithms can cause image noise to be spatially correlated. Noise correlation is characterized by non-constant noise power spectral density and can negatively affect image quality. Although the literature explores ways to quantify the frequency dependence of noise in digital mammography, there is still a lack of studies that explore the effect of this phenomenon on clinical tasks. Thus, the aim of this work is to evaluate the impact of noise correlation on the quality of digital mammography and the detectability of lesions using a virtual clinical trial (VCT) tool. Considering the radiographic factors of a standard full-dose acquisition, VCT was used to generate two sets of images: one containing mammograms corrupted with correlated noise and the other with uncorrelated (white) noise. Clusters of five to seven microcalcifications of different sizes and shapes were computationally inserted into the images at regions of dense tissue. We then designed a human observer study to investigate performance on a clinical task of locating microcalcifications on digital mammography from both image sets. In addition, nine objective image quality metrics were calculated on mammograms. The results obtained with four medical physicists showed that the average performance in localization was 72% for images with correlated noise and 95% with uncorrelated noise. Thus, our results suggest that correlated noise promotes a greater reduction in the conspicuity of subtle microcalcifications than uncorrelated noise. Furthermore, only four of the nine objective quality metrics calculated in this work were consistent with the results of the human observer study, highlighting the importance of using appropriate metrics to assess the quality of corrupted images with correlated noise. The source code for our framework is publicly available at https://github.com/LAVI-USP/SPIE2023-ImageQuality.

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Lucas E. Soares, Renann F. Brandao, Lucas R. Borges, Renato F. Caron, Bruno Barufaldi, Andrew D. A. Maidment, and Marcelo A. C. Vieira "Assessing the impact of correlated noise in digital mammography: a virtual clinical trial", Proc. SPIE 12467, Medical Imaging 2023: Image Perception, Observer Performance, and Technology Assessment, 1246714 (3 April 2023); https://doi.org/10.1117/12.2654111

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