Evaluation of cerebral 31-P chemical shift images utilizing statistical parametric mapping

Stefan Riehemann; Christian Gaser; Hans-Peter Volz; Heinrich Sauer

doi:10.1117/12.348516

21 May 1999 Evaluation of cerebral 31-P chemical shift images utilizing statistical parametric mapping

Stefan Riehemann, Christian Gaser, Hans-Peter Volz, Heinrich Sauer

Proceedings Volume 3661, Medical Imaging 1999: Image Processing; (1999) https://doi.org/10.1117/12.348516
Event: Medical Imaging '99, 1999, San Diego, CA, United States

Abstract

We present an evaluation technique of two dimensional (2D) nuclear magnetic resonance (NMR) chemical shift images (CSI) to analyze spatial differences of metabolite distributions and/or concentrations between groups of probands. Thus, chemical shift imaging is not only used as localization technique for NMR-spectroscopy, but the information of the complete spectroscopic image is used for the evaluation process. ³¹P CSI of the human brain were acquired with a Philips Gyroscan ACSII whole-body scanner at 1.5 T. CSI for different phosphorus metabolites were generated, all representing the same anatomical location. For each metabolite the CSI of two groups of subjects were compared with each other using the general linear model implemented in the widely distributed SPM96 software package. With this approach, even covariates or confounding variables like age or medication can be considered. As an example for the application of this technique, variations in the distribution of the ³¹P metabolite phosphocreatin between unmedicated schizophrenic patients and healthy controls were visualized. To our knowledge, this is the first approach to analyze spatial variations in metabolite concentrations between groups of subjects on the basis of chemical shift images. The presented technique opens a new perspective in the evaluation of 2D NMR spectroscopic data.

Citation Download Citation

Stefan Riehemann, Christian Gaser, Hans-Peter Volz, and Heinrich Sauer "Evaluation of cerebral 31-P chemical shift images utilizing statistical parametric mapping", Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); https://doi.org/10.1117/12.348516

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available