Incorporation of negative regions in a knowledge-based computer-aided detection scheme

Yuan-Hsiang Chang; Xiao Hui Wang; Lara A. Hardesty M.D.; Christiane M. Hakim M.D.; Bin Zheng; Walter F. Good; David Gur

doi:10.1117/12.467215

9 May 2002 Incorporation of negative regions in a knowledge-based computer-aided detection scheme

Yuan-Hsiang Chang, Xiao Hui Wang, Lara A. Hardesty M.D., Christiane M. Hakim M.D., Bin Zheng, Walter F. Good, David Gur

Proceedings Volume 4684, Medical Imaging 2002: Image Processing; (2002) https://doi.org/10.1117/12.467215
Event: Medical Imaging 2002, 2002, San Diego, California, United States

Abstract

The purpose was to evaluate the effect of incorporating negative but suspicious regions into a knowledge-based computer-aided detection (CAD) scheme of masses depicted in mammograms. To determine if a suspicious region is positive for a mass, the region was compared not only with actually positive regions (masses), but also with known negative regions. A set of quantitative measures (i.e., a positive, a negative, and a combined likelihood measure) was computed. In addition, a process was developed to integrate two likelihood measures that were derived using two selected features. An initial evaluation with 300 positive and 300 negative regions was performed to determine the parameters associated with the likelihood measures. Then, an independent set of 500 positive and 500 negative regions was used to test the performance of the CAD scheme. During the training phase, the performance was improved from Az=0.83 to 0.87 with the incorporation of negative regions and the integration process. During the independent test, the performance was improved from Az=0.80 to 0.83. The incorporation of negative regions and the integration process was found to add information to the scheme. Hence, it may offer a relatively robust solution to differentiate masses from normal tissue in mammograms.

Citation Download Citation

Yuan-Hsiang Chang, Xiao Hui Wang, Lara A. Hardesty M.D., Christiane M. Hakim M.D., Bin Zheng, Walter F. Good, and David Gur "Incorporation of negative regions in a knowledge-based computer-aided detection scheme", Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); https://doi.org/10.1117/12.467215

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available