Structural template formation with discovery of subclasses

Xiaojing Long; Chris Wyatt

doi:10.1117/12.843994

12 March 2010 Structural template formation with discovery of subclasses

Xiaojing Long, Chris Wyatt

Proceedings Volume 7623, Medical Imaging 2010: Image Processing; 76231B (2010) https://doi.org/10.1117/12.843994
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

A major focus of computational anatomy is to extract the most relevant information to identify and characterize anatomical variability within a group of subjects as well as between different groups. The construction of atlases is central to this effort. An atlas is a deterministic or probabilistic model with intensity variance, structural, functional or biochemical information over a population. To date most algorithms to construct atlases have been based on a single subject assuming that the population is best described by a single atlas. However, we believe that in a population with a wide range of subjects multiple atlases may be more representative since they reveal the anatomical differences and similarities within the group. In this work, we propose to use the K-means clustering algorithm to partition a set of images into several subclasses, based on a joint distance which is composed of a distance quantifying the deformation between images and a dissimilarity measured from the registration residual. During clustering, the spatial transformations are averaged rather than images to form cluster centers, to ensure a crisp reference. At the end of this algorithm, the updated centers of the k clusters are our atlases. We demonstrate this algorithm on a subset of a public available database with whole brain volumes of subjects aged 18-96 years. The atlases constructed by this method capture the significant structural differences across the group.

Citation Download Citation

Xiaojing Long and Chris Wyatt "Structural template formation with discovery of subclasses", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76231B (12 March 2010); https://doi.org/10.1117/12.843994

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