Model-based blood flow quantification from DSA: quantitative evaluation on patient data and comparison with TCCD

I. Waechter-Stehle; A. Groth; T. Bruijns; O. Brina; D. A. Ruefenacht; Z. Kulcsar; V. Mendes-Pereira; F. Perren; D. J. Hawkes; J. Weese

doi:10.1117/12.911095

24 February 2012 Model-based blood flow quantification from DSA: quantitative evaluation on patient data and comparison with TCCD

I. Waechter-Stehle, A. Groth, T. Bruijns, O. Brina, D. A. Ruefenacht, Z. Kulcsar, V. Mendes-Pereira, F. Perren, D. J. Hawkes, J. Weese

Author Affiliations +

Proceedings Volume 8314, Medical Imaging 2012: Image Processing; 83144R (2012) https://doi.org/10.1117/12.911095
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

Purpose: To support intra-interventional decisions on diagnosis and treatment of cerebrovascular diseases, a method providing quantitative information about the blood flow in the vascular system is proposed. Method: This method combines rotational angiography to extract the 3D vessel geometry and digital subtraction angiography (DSA) to obtain the flow observations. A physical model of blood flow and contrast agent transport is used to predict the propagation of the contrast agent through the vascular system. In an iterative approach, the model parameters, including the volumetric blood flow rate, are adapted until the prediction matches the observations from the DSA. The flow estimation method was applied to patient data: For 24 patients, the volumetric blood flow rate was determined from angiographic images and for 17 patients, results were compared with transcranial color coded Doppler (TCCD) measurements. Results: The agreement of the x-ray based flow estimates with TCCD was reasonable (bias Δ_M = 3%, correlation ρ = 0.76) and reproducibility was clearly better than the reproducibility of the acquired TCCD measurements. Conclusion: Overall we conclude that it is feasible to model the contrast agent transport in patients and to utilize the flow model to quantify their blood flow with angiographic means.

Citation Download Citation

I. Waechter-Stehle, A. Groth, T. Bruijns, O. Brina, D. A. Ruefenacht, Z. Kulcsar, V. Mendes-Pereira, F. Perren, D. J. Hawkes, and J. Weese "Model-based blood flow quantification from DSA: quantitative evaluation on patient data and comparison with TCCD", Proc. SPIE 8314, Medical Imaging 2012: Image Processing, 83144R (24 February 2012); https://doi.org/10.1117/12.911095

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available