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Forensic genomics: kin privacy, driftnets and other open questions

Published:27 October 2008Publication History

ABSTRACT

DNA analysis is increasingly used in forensics, where it is being pushed as the holy grail of identification. But we are approaching a dramatic "phase change" as we move from genetics to genomics: when sequencing the entire genome of a person becomes sufficiently cheap as to become a routine operation, as is likely to happen in the coming decades, then each DNA examination will expose a wealth of very sensitive personal information about the examined individual, as well as her relatives. In this interdisciplinary discussion paper we highlight the complexity of DNA-related privacy issues as we move into the genomic (as opposed to genetic) era: the "driftnet" approach of comparing scene-of-crime samples against the DNA of the whole population rather than just against that of chosen suspects; the potential for errors in forensic DNA analysis and the consequences on security and privacy; the civil liberties implications of the interaction between medical and forensic applications of genomics. For example, your kin can provide valuable information in a database matching procedure against you even if you don't; and being able to read the whole of a sampled genome, rather than just 13 specific markers from it, provides information about the medical and physical characteristics of the individual.

Our aim is to offer a simple but thought-provoking and technically accurate summary of the many issues involved, hoping to stimulate an informed public debate on the statutes by which DNA collection, storage and processing should be regulated.

References

  1. "New Grants Drive Development Of Rapid, Cost-Effective Sequencing Technologies", Medical News Today, 2008--08--23, http://www.medicalnewstoday.com/articles/118963.phpGoogle ScholarGoogle Scholar
  2. http://www.iht.com/articles/2007/06/01/america/dna.phpGoogle ScholarGoogle Scholar
  3. http://www.nytimes.com/2007/12/12/science/12watson.htmlGoogle ScholarGoogle Scholar
  4. Gill P, Ivanov PL, Kimpton C, Piercy R, Benson N, Tully G, Evett I, Hagelberg E, Sullivan K. "Identification of the remains of the Romanov family by DNA analysis". Nat Genet. 1994 Feb;6(2):130--5.Google ScholarGoogle Scholar
  5. Balding, D. J. and Donnelly, P. (1995). "Inference in forensic identification". Journal of the Royal Statistical Society, Series A 158, 21--53.Google ScholarGoogle ScholarCross RefCross Ref
  6. BBC News. "Germany adopts Stasi scent tactic". 2007--05--23. http://news.bbc.co.uk/1/hi/world/europe/6683803.stmGoogle ScholarGoogle Scholar
  7. Philip Bohannon, Markus Jakobsson, Sukamol Srikwan. "Cryptographic Approaches to Privacy in Forensic DNA Databases". In Public Key Cryptography 2000, pp. 373--390. Jan, 2000. Google ScholarGoogle ScholarDigital LibraryDigital Library
  8. Helm, T.: "Outrage at 500,000 DNA database mistakes". Telegraph, 2007-08-27 http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2007/08/27/ndna127.xmlGoogle ScholarGoogle Scholar
  9. Balding D., Donnelly P. (1996) "Evaluating DNA Profile Evidence When the Suspect Is Identified Through a Database Search". J Forensic Sci 41, 603--607.Google ScholarGoogle Scholar
  10. National Research Council (NRC). "The evaluation of forensic DNA evidence". Technical report, National Academy Press, Washington D. C., 1996.Google ScholarGoogle Scholar
  11. Singh SM, Murphy B, O'Reilly R. "Epigenetic contributors to the discordance of monozygotic twins". Clin Genet. 2002 Aug; 62(2):97--103.Google ScholarGoogle Scholar
  12. Phillip R. Garrison (Judge), Adams vs Miller and Miller, Case number 27188, 2007--03--14, Missouri Court of Appeals Southern District, http://www.courts.mo.gov/Courts/PubOpinions. nsf/8e937ac7ce0301288625661f004bc963/67393c1c232272598625729e0075ff81? OpenDocument.Google ScholarGoogle Scholar
  13. Hsien-Hsien Lei, "Genetic Differences Between Identical Twins", http://www.eyeondna.com/2008/02/page/2/, 2008--02--20.Google ScholarGoogle Scholar
  14. Testimony of Philip R. Zimmermann to the Subcommittee on Science, Technology, and Space of the US Senate Committee on Commerce, Science, and Transportation. 1996--06--26. http://www.philzimmermann.com/EN/testimony/index.htmlGoogle ScholarGoogle Scholar
  15. Frederick R Bieber, Charles H Brenner and David Lazer, "Finding Criminals Through DNA of Their Relatives", Sciencexpress, 2006--05--11.Google ScholarGoogle Scholar
  16. Donnelly, P. and Friedman, D. "DNA database searches and the legal consumption of scientific evidence", Michigan Law Review 97, 931--984, 1999.Google ScholarGoogle ScholarCross RefCross Ref
  17. Storvik, G. and Egeland, TB. "The DNA database search controversy revisited: Bridging the Bayesian - Frequentistic gap". Biometrics 63 pp 922--925, 2007.Google ScholarGoogle ScholarCross RefCross Ref
  18. Pan Q, Luo X, Chegini N. "Genomic and proteomic profiling I: leiomyomas in African Americans and Caucasians". Reprod Biol Endocrinol. 2007 Aug 23; 5:34.Google ScholarGoogle Scholar
  19. Collins-Schramm HE, Phillips CM, Operario DJ, Lee JS, Weber JL, Hanson RL, Knowler WC, Cooper R, Li H, Seldin MF. "Ethnic-difference markers for use in mapping by admixture linkage disequilibrium". Am J Hum Genet. 2002 Mar;70(3):737--50. Epub 2002 Feb 11.Google ScholarGoogle ScholarCross RefCross Ref
  20. Collins T, "Loss of 1.3 million sensitive medical files in the US", ComputerWeekly, July 2007, http://www.computerweekly.com/blogs/tony_collins/2007/07/loss-of-13-million-sensitive-m.html.Google ScholarGoogle Scholar
  21. BBC, "Thousands of driver details lost", 2007-12-11, http://news.bbc.co.uk/1/hi/northern_ireland/7138408.stm.Google ScholarGoogle Scholar
  22. B. Heffernan and E. Kennedy, "Alert as 170,000 blood donor files are stolen", 2008-02-20, http://www.independent.ie/national-news/alert-as-170000-blood-donor-files-are-stolen-1294079.html.Google ScholarGoogle Scholar
  23. Council of Europe, European Convention on Bio-medicine (ETS 164, the "Oviedo Convention"), Art. 11.Google ScholarGoogle Scholar
  24. EU Charter of Fundamental Rights, Art. 21.Google ScholarGoogle Scholar
  25. UNESCO, "Universal Declaration on Human Genome and Human Rights", Article 6.Google ScholarGoogle Scholar
  26. "US House Passes Genetic Discrimination Bill", Genome Web News, New York, 1 May 2008.Google ScholarGoogle Scholar
  27. Article 29 Working Party (WP), "Working Document on Genetic Data" (WP 91 of 17 March 2004).Google ScholarGoogle Scholar
  28. Article 29 Working Party (WP), "Opinion 6/2000 on the Genome Issue" (WP 34 of 13th July 2000)Google ScholarGoogle Scholar
  29. Article 29 Working Party (WP), "Working Document on Biometrics" (WP 80 of 1 August 2003).Google ScholarGoogle Scholar
  30. D. Korff, "The need to apply UK data protection law in accordance with European law", Data Protection Law & Policy, May 2008.Google ScholarGoogle Scholar
  31. D. Korff, "Study on Implementation of Data Protection Directive -- Comparative Summary of National Laws", Study for the EC Commission, 2003.Google ScholarGoogle Scholar
  32. R Anderson, I Brown, R Clayton, T Dowty, D Korff, E Munro. "Children's Databases -- Safety and Privacy" (2006), FIPR study for the UK Information Commissioner.Google ScholarGoogle Scholar
  33. BBC, "All UK must be on DNA database", BBC News, 5 September 2007 http://news.bbc.co.uk/1/hi/uk/6979138.stmGoogle ScholarGoogle Scholar
  34. "Britain needs DNA database, says officer who headed Sally Anne murder inquiry", Times Online, 22 February 2008.Google ScholarGoogle Scholar
  35. "Mandatory DNA database rejected", BBC News, 23 February 2008 http://news.bbc.co.uk/1/hi/uk/7260164.stm.Google ScholarGoogle Scholar
  36. Genewatch, "The UK Police National DNA Database" http://www.genewatch.org/sub-539478.Google ScholarGoogle Scholar
  37. "The 100 dollars Genome". Technology Review, published by MIT, April 17, 2008. http://www.technologyreview.com/Biotech/20640/page1/Google ScholarGoogle Scholar
  38. P. Kuzniar, E. Jastrzebska, R. Ploski. "Validation of nine non-CODIS STR loci for forensic use in a population from Central Poland". Forensic Science International, Volume 159, Issue 2--3 , Pages 258--260.Google ScholarGoogle Scholar
  39. J S. Barnholtz-Sloan, R Chakraborty, T A. Sellers and A G.Schwartz. "Examining Population Stratification via Individual Ancestry Estimates versus Self-Reported Race". Cancer Epidemiology Biomarkers and Prevention Vol. 14, 1545--1551, June 2005.Google ScholarGoogle ScholarCross RefCross Ref
  40. Harris MA et al., Gene Ontology Consortium. "The Gene Ontology (GO) database and informatics resource". Nucleic Acids Res. 2004 Jan 1;32 (Database issue): D258--61.Google ScholarGoogle Scholar
  41. Ashburner M, Lewis S. "On ontologies for biologists: the Gene Ontology-untangling the web". Novartis Found Symp. 2002;247:66--80; discussion 80-3, 84--90, 244--52.Google ScholarGoogle Scholar
  42. Gilks WR, Audit B, de Angelis D, Tsoka S, Ouzounis CA. "Percolation of annotation errors through hierarchically structured protein sequence databases." Math Biosci. 2005 Feb;193(2):223--34.Google ScholarGoogle Scholar
  43. Jacoby E. "Chemogenomics: drug discovery's panacea?" Mol Biosyst. 2006 May;2(5):218--20. Epub 2006 Mar 30.Google ScholarGoogle ScholarCross RefCross Ref
  44. "Simpson lawyers switch emphasis to police errors". USA Today http://www.usatoday.com/news/index/nns133.htmGoogle ScholarGoogle Scholar
  45. "What is the chance of your being guilty?" Financial Times 19 June 2003. http://www.johnkay.com/society/287Google ScholarGoogle Scholar
  46. "Evaluating Legal Evidence". Department of Computer Science, Queen Mary University 9 May 2008. http://www.dcs.qmul.ac.uk/researchgp/spotlight/legal.htmlGoogle ScholarGoogle Scholar
  47. Levinson DF, Holmans P. "The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees." BMC Genet. 2005 Dec 30;6 Suppl 1:S6.Google ScholarGoogle Scholar
  48. Gasbarra D, Pirinen M, Sillanpää MJ, Arjas E. "Estimating genealogies from linked marker data: a Bayesian approach." BMC Bioinformatics. 2007 Oct 25;8:41.Google ScholarGoogle Scholar
  49. Nebel A, Filon D, Brinkmann B, Majumder PP, Faerman M, Oppenheim A. "The Y chromosome pool of Jews as part of the genetic landscape of the Middle East." Am J Hum Genet. 2001 Nov;69(5):1095--112.Google ScholarGoogle Scholar
  50. R v Doheny and Adams {1997} 1 Crim App R 369.Google ScholarGoogle Scholar

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    • Published in

      cover image ACM Conferences
      WPES '08: Proceedings of the 7th ACM workshop on Privacy in the electronic society
      October 2008
      128 pages
      ISBN:9781605582894
      DOI:10.1145/1456403

      Copyright © 2008 ACM

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      Publication History

      • Published: 27 October 2008

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