Priyakshi Mahanta
ABSTRACT
Recently, finding locally dense regions referred to as complexes from large protein-protein interaction (PPI) datasets modeled as a PPI network has received a serious attention among the bioinformatic researchers. Such protein complexes play key role in many biological processes and hence considered to be an important task in post-genomic era. This paper addresses the problem of identifying protein complexes from the protein-protein interaction network using a graph density approach. The effectiveness of our protein complex extraction method referred to as 'PDComp' has been established in terms of well known p value, co-localization score and physical interaction. Our results show that the technique is capable of detecting biologically significant protein complexes from the PPI networks
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- PDComp: An Effective PPI complex Finding Method
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