Differential Evolution Analysis of Clinical Characteristics of Severe Viral Pneumonia in Children

The effects of acetylcysteine on the proliferation of lung fibroblasts in normal and severe viral pneumonia children were compared. Children with severe viral pneumonia and normal lung fibroblasts were isolated and cultured, and the effects of lung fibroblast proliferation and acetylcysteine on normal lung fibroblasts and children with severe viral pneumonia were observed, the effect of acetylcysteine dose gradient on the proliferation of alveolar epithelial cell A549 was compared. It can inhibit the proliferation of lung fibroblasts in both normal and severe viral pneumonia children. Then, the improved two-stage differential evolution algorithm was used to optimize the clinical characteristics of severe viral pneumonia in children by aerosol inhalation of acetylcysteine, the results showed that the inhibitory effect of acetylcysteine was dose-dependent in normal lung fibroblasts, and cell proliferation was basically stopped when the concentration reached 40 mM. However, the inhibitory effect of acetylcysteine on the proliferation of pulmonary fibroblasts in children with severe viral pneumonia did not increase with the increase of concentration, and the cell proliferation continued at 40 mM. Acetylcysteine can inhibit the proliferation of lung fibroblasts, and the inhibitory effect has cell specificity in a certain concentration range.