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Model-based variational smoothing and segmentation for diffusion tensor imaging in the brain

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Abstract

This article applies a unified approach to variational smoothing and segmentation to brain diffusion tensor image data along user-selected attributes derived from the tensor, with the aim of extracting detailed brain structure information. The application of this framework simultaneously segments and denoises to produce edges and smoothed regions within the white matter of the brain that are relatively homogeneous with respect to the diffusion tensor attributes of choice. This approach enables the visualization of a smoothed, scale invariant representation of the tensor data field in a variety of diverse forms. In addition to known attributes such as fractional anisotropy, these representations include selected directional tensor components and additionally associated continuous valued edge fields that might be used for further segmentation. A comparison is presented of the results of three different data model selections with respect to their ability to resolve white matter structure. The resulting images are integrated to provide better perspective of the model properties (edges, smoothed image, and so forth) and their relationship to the underlying brain anatomy. The improvement in brain image quality is illustrated both qualitatively and quantitatively, and the robust performance of the algorithm in the presence of added noise is shown. Smoothing occurs without loss of edge features because of the simultaneous segmentation aspect of the variational approach, and the output enables better delineation of tensors representative of local and long-range association, projection, and commissural fiber systems.

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Authors and Affiliations

  1. Control and Information Systems Division, C.S. Draper Laboratory, 02139, Cambridge, MA

    Mukund Desai & Rami Mangoubi

  2. Center for Morphometric Analysis and MGH/MIT Athinoula A. Martinos Center for Biomedical Imaging, Department of Neurology, Massachusetts General Hospital, 02129, Boston, MA

    David N. Kennedy & Nikos Makris

  3. Department of Mathematics, Northeastern University, 02115, Boston, MA

    Jayant Shah

  4. Electrical, Computer, and System Engineering Department, and Biomedical Engineering Department, Boston University, 02215, Boston, MA

    Clem Karl

  5. Neuromorphometrics, 02144, Somerville, MA

    Andrew Worth

  6. MGH-HST Center for Biomarkers in Imaging, Department of Radiology, Massachusetts General Hospital, 02129, Ma

    Homer Pien

Authors
  1. Mukund Desai
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  2. David N. Kennedy
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  3. Rami Mangoubi
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  7. Nikos Makris
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  8. Homer Pien
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Correspondence to Mukund Desai.

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Desai, M., Kennedy, D.N., Mangoubi, R. et al. Model-based variational smoothing and segmentation for diffusion tensor imaging in the brain. Neuroinform 4, 217–233 (2006). https://doi.org/10.1385/NI:4:3:217

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