The impact of intersymbol interference (ISI) on single carrier frequency domain equalization with multiple input multiple output (MIMO-SCFDE) systems is severe. Most existing channel equalization methods fail to solve it completely. In this paper, given the disadvantages of the error propagation and the gap from matched filter bound (MFB), we creatively introduce a decision feedback equalizer with frequency-domain bidirectional noise prediction (DFE-FDBiNP) to tackle intersymbol interference (ISI) in MIMO-SCFDE systems. The equalizer has two-part equalizer, that is the normal mode and the time-reversal mode decision feedback equalization with noise prediction (DFE-NP). Equal-gain combining is used to realize a greatly simplified and low complexity diversity combining. Analysis and simulation results validate the improved performance of the proposed method in quasi-static frequency-selective fading MIMO channel for a typical urban environment.