We propose a time-frequency interleave (TFI) structure of single carrier (SC) frequency domain equalization (FDE) to combat spectral nulls of wireless channels. Permuted copies of block data are transmitted in the TFI-FDE, providing the same diversity order as maximal-ratio receiver combining. The spectral nulls are compensated by uncorrelated spectral components of the same channel. It shows 4dB diversity gains at BER of 10^-2 over an indoor channel. The TFI-FDE is computationally-efficient in combination with fast Fourier transform. This TFI-FDE fits SC systems with single antenna. It needs no channel state information at the transmitter.