Wireless sensor networks (WSN) is composed of so many small sensor nodes which have limited resources. So the technique that raises energy efficiency is the key to prolong the network life time. In the paper, we propose an agent based framework which takes the biological characteristics of gene. The gene represents an operation policy to control agent behavior. Agents are aggregated to reduce duplicate transmissions in active period. And it selects next hop based on the information of neighbor agents. Among neighbors, the node which has enough energy is given higher priority. The base station processes genetic evolution to refine the behavior policy of agent. Each agent is taken latest gene and spread recursively to find the optimal gene. Our proposed framework yields sensor nodes that have the properties of self-healing, self-configuration, and self-optimization. Simulation results show that our proposed framework increases the lifetime of each node.