In this paper, a new analog signal transmission technique called analog single-carrier transmission with frequency-domain equalization (analog SC-FDE) is proposed. Analog SC-FDE applies discrete Fourier transform (DFT), frequency-domain spectrum shaping and mapping, inverse DFT (IDFT), and cyclic prefix (CP) insertion before transmission. At the receiver, one-tap FDE is applied to take advantage of frequency diversity. This paper considers, as an example, analog voice transmission. A theoretical analysis of the normalized mean square error (NMSE) performance is carried out to evaluate the transmission property of the proposed analog SC-FDE and is confirmed by computer simulation. We show that analog SC-FDE achieves better NMSE performance than conventional analog signal transmission scheme.