In this paper, we present a classification method for a Computer-Aided Diagnosis (CAD) system in a colorectal magnified Narrow Band Imaging (NBI) endoscopy. In an endoscopic video image, color shift, blurring or reflection of light occurs in a lesion area, which affects the discrimination result by a computer. Therefore, in order to identify lesions with high robustness and stable classification to these images specific to video frame, we implement a CAD system for colorectal endoscopic images with the Convolutional Neural Network (CNN) feature and Support Vector Machine (SVM) classification on the embedded DSP core. To improve the robustness of CAD system, we construct the SVM learned by multiple image sizes data sets so as to adapt to the noise peculiar to the video image. We confirmed that the proposed method achieves higher robustness, stable, and high classification accuracy in the endoscopic video image. The proposed method also can cope with differences in resolution by old and new endoscopes and perform stably with respect to the input endoscopic video image.