Time variation within an OFDM symbol causes inter-carrier interference (ICI). In this letter, frequency-domain partial response coding (PRC) is investigated to reduce ICI in the Alamouti SFBC-OFDM system. Based on the expression of the ICI power in the SFBC-OFDM system with PRC, the near-optimal weights of PRC are derived. Simulation results show that the PRC scheme can reduce ICI effectively.