This study focuses on system throughput by taking into account the channel interference in IEEE 802.15.3c WPAN, which is based on the hybrid multiple access of CSMA/CA and TDMA, namely CSMA/CA-TDMA. To study the system throughput, we construct a novel analytical model by taking into consideration the channel interference caused by the hidden networks in CSMA/CA-TDMA. The obtained results show that the system throughput achieved by TDMA is highly affected by frame transmission in CSMA/CA. Furthermore, we show that channel interference, which causes a degradation in the system throughput, is a very significant problem in the IEEE 802.15.3c WPAN.