A low peak-to-average-power-ratio (PAPR) transceiver with a time-frequency cyclic shift orthogonal keying (TF-CSOK) technique is proposed for the uplink multi-carrier CDMA (MC-CDMA) system over multiple access interference (MAI) and multipath interference (MPI) channels. The low complexity structure of the TF-CSOK MC-CDMA system is designed to involve the FCSOK and TCSOK techniques to combat MPI and MAI effects, respectively. In particular, at the besestation, the multiuser detector employs the maximum likelihood (ML) rule and the TFSOK despreading and demapping techniques to acquire the M-ary modulation gain and diversity gain. Simulation results show that the multuser receiver has the robustness against strong MAI. Moreover, it outperforms the conventional single-carrier frequency division multiple access (SC-FDMA) system and the conventional MC-CDMA system under MAI and MPI environments.