IEICE Transactions on Electronics
Online ISSN : 1745-1353
Print ISSN : 0916-8524
Special Section on Analog Circuits and Their Application Technologies
Sub-1-V CMOS-Based Electrophoresis Using Electroless Gold Plating for Small-Form-Factor Biomolecule Manipulation
Yuuki YAMAJIKazuo NAKAZATOKiichi NIITSU
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2017 Volume E100.C Issue 6 Pages 592-596

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Abstract

In this paper, we present sub-1-V CMOS-based electrophoresis method for small-form-factor biomolecule manipulation that is contained in a microchip. This is the first time this type of device has been presented in the literature. By combining CMOS technology with electroless gold plating, the electrode pitch can be reduced and the required input voltage can be decreased to less than 1 V. We fabricated the CMOS electrophoresis chip in a cost-competitive 0.6 µm standard CMOS process. A sample/hold circuit in each cell is used to generate a constant output from an analog input. After forming gold electrodes using an electroless gold plating technique, we were able to manipulate red food coloring with a 0-0.7 V input voltage range. The results shows that the proposed CMOS chip is effective for electrophoresis-based manipulation.

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© 2017 The Institute of Electronics, Information and Communication Engineers
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