IEICE Transactions on Electronics
Online ISSN : 1745-1353
Print ISSN : 0916-8524
Special Section on Recent Progress in Superconducting Analog Devices and Their Applications
Liquid-Phase Detection of Biological Targets with Magnetic Marker and Superconducting Quantum Interference Device
Keiji ENPUKU, Yuki SUGIMOTO, Yuya TAMAI, Akira TSUKAMOTO, Takako MIZOGUCHI, Akihiko KANDORI, Naoki USUKI, Hisao KANZAKI, Kohji YOSHINAGA, Yoshinori SUGIURA, Hiroyuki KUMA, Naotaka HAMASAKI
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Keywords: liquid-phase immunoassay, magnetic marker, Brownian relaxation, Neel relaxation, B/F separation, SQUID
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2009 Volume E92.C Issue 3 Pages 315-322

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Abstract

Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotin-coated polymer beads, IgE and Candida albicans.

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© 2009 The Institute of Electronics, Information and Communication Engineers
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