In this letter, we propose a low complexity fixed sphere decoder (FSD) with statistical threshold for multiple-input and multiple-output (MIMO) systems. The proposed algorithm is developed by applying two threshold-based pruning algorithms using an initial detection and statistical noise constraint to the FSD. The proposed FSD algorithm is suitable for a fully pipelined hardware implementation and also has low complexity because the threshold of the proposed pruning algorithm is pre-calculated and independently applied to the path without sorting operation. Simulation results show that the proposed FSD has the performance of the original FSD as well as a low complexity compared to the original FSD and other low complexity FSD algorithms.